6-BROMO-4-CHLORO-2-(2-FLUORO-PHENYL)-QUINAZOLINE synthesis

Yield:760947-12-4 90%

Reaction Conditions:

with thionyl chloride;N,N-dimethyl-formamide in chloroform at 0 - 80; for 4 h;

Steps:

3.D Step D: Preparation of 6-BROMO-4-CHLORO-2- (2-FLUORO- PHENYL)-QUINAZOLINE

6-BROMO-2- (2-FLUORO-PHENYL)-3H-QUINAZOLIN-4-ONE from Step C (1.5g, 4. 6MMOL) was suspended in chloroform in a 50ML round bottomed flask equipped with magnetic stirrer. The flask was cooled to 0°C and to it was added thionyl chloride (1. 6ml) drop wise followed by N, N-dimethyl formamide (0. 01ML) and the mixture heated to 80°C for 4hrs. The solvent was removed by evaporation in a rotary evaporator to leave a title compound as a solid (1.43g, 90%). MS (ES) 338 (M+H) +

References:

WO2004/81009,2004,A1 Location in patent:Page 48