![](/CAS/GIF/885520-23-0.gif)
6-BROMO-4-FLUORO-1H-INDAZOLE synthesis
- Product Name:6-BROMO-4-FLUORO-1H-INDAZOLE
- CAS Number:885520-23-0
- Molecular formula:C7H4BrFN2
- Molecular Weight:215.02
![4-Bromo-2,6-difluorobenzaldehyde](/CAS/GIF/537013-51-7.gif)
537013-51-7
224 suppliers
$10.00/100mg
![6-BROMO-4-FLUORO-1H-INDAZOLE](/CAS/GIF/885520-23-0.gif)
885520-23-0
156 suppliers
$42.00/250mg
Yield: 100%
Reaction Conditions:
with hydrazine hydrate in ethylene glycol at 95; for 2 h;Inert atmosphere;
Steps:
5.1.13. 6-Bromo-4-fluoro-1H-indazole (21)
To a stirred suspension of 4-bromo-2,6-difluorobenzaldehyde 20 (commercially available, CAS 537013-51-7, 442.0 mg, 2.00 mmol) in ethylene glycol (10 mL) at ambient temperature was added hydrazine monohydrate (0.19 mL, 4.00 mmol). The resulting suspension was heated to 95 C under nitrogen for 2 h.The reaction was then cooled to 5 C and diluted with water. The solution was extracted with ethyl acetate, dried over anhydrous Na2SO4, and concentrated to yield 6-bromo-4-fluoro-1H-indazole 21 (430.0 mg, 100%) as a yellow solid.
References:
Qian, Shan;He, Tao;Wang, Wei;He, Yanying;Zhang, Man;Yang, Lingling;Li, Guobo;Wang, Zhouyu [Bioorganic and Medicinal Chemistry,2016,vol. 24,# 23,p. 6194 - 6205]
![6-bromo-4-fluoro-1H-indazol-3-amine](/CAS/20180601/GIF/1227912-19-7.gif)
1227912-19-7
35 suppliers
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![6-BROMO-4-FLUORO-1H-INDAZOLE](/CAS/GIF/885520-23-0.gif)
885520-23-0
156 suppliers
$42.00/250mg
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886761-86-0
36 suppliers
$90.00/50mg
![6-BROMO-4-FLUORO-1H-INDAZOLE](/CAS/GIF/885520-23-0.gif)
885520-23-0
156 suppliers
$42.00/250mg
![4-Bromo-2,6-difluorobenzonitrile](/CAS/GIF/123843-67-4.gif)
123843-67-4
251 suppliers
$5.00/250mg
![6-BROMO-4-FLUORO-1H-INDAZOLE](/CAS/GIF/885520-23-0.gif)
885520-23-0
156 suppliers
$42.00/250mg
![1-Bromo-3,5-difluorobenzene](/CAS/GIF/461-96-1.gif)
461-96-1
475 suppliers
$6.00/10g
![6-BROMO-4-FLUORO-1H-INDAZOLE](/CAS/GIF/885520-23-0.gif)
885520-23-0
156 suppliers
$42.00/250mg