6-Bromo-5-fluoro-3,4-dihydro-1H-quinolin-2-one synthesis

4synthesis methods

Product Name:6-Bromo-5-fluoro-3,4-dihydro-1H-quinolin-2-one
CAS Number:1404367-69-6
Molecular formula:C9H7BrFNO
Molecular Weight:244.06

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6-Bromo-5-fluoro-3,4-dihydro-1H-quinolin-2-one

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Yield:1404367-69-6 68%

Reaction Conditions:

with NBS in N,N-dimethyl-formamide at 20;Cooling with ice;

Steps:

21.5 Step 5: 6-bromo-5-fluoro-3,4-dihydroquinolin-2(1H)-one

Ice bath,The compound 5-fluoro-3,4-dihydroquinolin-2 (1H) -one (0.32 g, 1.94 mmol) was dissolved in N, N-dimethylformamide (6 mL)Then N-bromosuccinimide (0.38 g, 2.13 mmol) was added to the reaction system,Stir overnight at room temperature.The reaction solution was poured into ice water, solidified, filtered and air dried to give 6-bromo-5-fluoro-3,4-dihydroquinolin-2 (1H) -one (0.32 g) in 68% yield.

References:

CN106349241,2017,A Location in patent:Paragraph 0442; 0456; 0457; 0458; 0459

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References

Propanedioic acid, 2-[(2-fluoro-6-nitrophenyl)methyl]-, 1,3-diethyl ester

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References

769-10-8 Synthesis

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References