6-BROMO-5-METHYLBENZO[D]THIAZOL-2-AMINE synthesis

2synthesis methods

Product Name:6-BROMO-5-METHYLBENZO[D]THIAZOL-2-AMINE
CAS Number:947248-62-6
Molecular formula:C8H7BrN2S
Molecular Weight:243.12

6933-10-4 Synthesis

6933-10-4
186 suppliers
$7.00/5g

333-20-0
434 suppliers
$13.50/100G

947248-62-6
12 suppliers
$276.74/250mg

947248-61-5 Synthesis

947248-61-5
12 suppliers
$223.44/250mg

Yield:-

Reaction Conditions:

with bromine;acetic acid at 26; for 18 h;

Steps:

52.A Step A. 6-bromo-7-methylbenzordlthiazol-2-amine and 6-bromo-5-methylbenzordlthiazol-2- amine

Step A. 6-bromo-7-methylbenzordlthiazol-2-amine and 6-bromo-5-methylbenzordlthiazol-2- amine To a solution of compound 3,4-dimethyl-aniline (7.1 g, 0.059 mol) in AcOH (1 10 mL), was added Br 2 (9.44 g, 0.059 mmol) and potassiumpotassium thiocyanate (5.7 g, 0.059 mmol) accordingly. The reaction mixture is stirred for 18 hrs at 26°C. The mixture was filtered. The filtrate was concentrated and partitioned by DCM and aq. Na₂C(. The organic layer was washed with water and brine, dried over Na2S0₄ and concentrated in vacuo to afford a crude mixture of two regioisomers: 6-bromo-7-methylbenzo[d]thiazol-2-amine and 6-bromo-5- methylbenzo[d]thiazol-2-amine which were separated by preparative HPLC to give the title compound.

References:

WO2015/89809,2015,A1 Location in patent:Page/Page column 91 WO2015/95256,2015,A1 Location in patent:Page/Page column 91

7745-91-7 Synthesis

7745-91-7
315 suppliers
$6.00/5g

947248-62-6
12 suppliers
$276.74/250mg

References