6-BroMo-7-fluoro-3,4-dihydroquinolin-2(1H)-one synthesis
- Product Name:6-BroMo-7-fluoro-3,4-dihydroquinolin-2(1H)-one
- CAS Number:1156389-00-2
- Molecular formula:C9H7BrFNO
- Molecular Weight:244.06
4590-52-7
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Yield:1156389-00-2 92%
Reaction Conditions:
with N-Bromosuccinimide in N,N-dimethyl-formamide at 0 - 20; for 4 h;
Steps:
1.1 6-bromo 7-fluoro-3,4-dihydro-lH-quinolin-2-one
7-fluoro-3,4-dihydroquinolin-2(lH)-one (1.00 g, 5.75 mmol) was dissolved in DMF (12 mL) and cooled to 0 °C. N-Bromosuccinimide (1.14 g, 6.33 mmol) was added in small portions, reaction mixture was warmed up to rt and stirred for 4h. The reaction mixture was poured into water and the white solid was filtered, washed with water, and dried. The crude soid was purified by flash chromatography to give 6-bromo-7-fluoro-3,4-dihydroquinolin- 2(lH)-one (1.28 g, 92%); 1H NMR (CHLOROFORM-d) δ: 9.21 (br s, 1H), 7.29-7.37 (m, 1H), 6.67 (d, 1H), 2.95 (br m, 2H), 2.65 (m, 2H).
References:
WO2017/34982,2017,A1 Location in patent:Paragraph 0169
372-19-0
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