ChemicalBook CAS DataBase List 6-broMo-8-Methoxyquinoline

6-broMo-8-Methoxyquinoline synthesis

5synthesis methods

Product Name:6-broMo-8-Methoxyquinoline
CAS Number:103028-32-6
Molecular formula:C10H8BrNO
Molecular Weight:238.08

6293-83-0 Synthesis

6293-83-0
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56-81-5 Synthesis

56-81-5
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$5.00/25g

103028-32-6
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Yield:103028-32-6 100%

Reaction Conditions:

with sulfuric acid;sodium 3-nitrobenzenesulfonate in water at 0 - 120; for 24.5 h;Inert atmosphere;

Steps:

Intermediate 49: 6-bromo-8-methoxyquinoline

4-Bromo-2-methoxyaniline (50.0 g, 247 mmol) was added to a mixture of sodium 3- nitrobenzenesulfonate (86.8 g, 385 mmol) and propane-1 ,2,3-triol (108 g, 1 .18 mol) in cone. H₂SO4 (97 ml.) and water (75.7 ml.) at 0 °C over a period of 30 min under nitrogen. After stirring at 120 °C for 24 h and then cooling to RT, the reaction mixture was quenched slowly with 2M NaOH (1 L). The aq. solution was extracted with EtOAc (3 x 500 ml_). The combined organic phases were dried over Na₂S04, filtered and concentrated to afford 6-bromo-8- methoxyquinoline (Intermediate 49, 60.0 g, 100%); M/Z (ES+), [M+H]⁺= 237.¹H NMR (300 MHz, DMSO-ofe) δ 3.99 (s, 3H), 7.30 (d, 1 H), 7.58-7.60 (m, 1 H), 7.79 (s, 1 H), 8.28 (dd, 1 H), 8.86 (dd, 1 H).

References:

WO2018/178226,2018,A1 Location in patent:Page/Page column 77

3054-95-3 Synthesis