6-Bromobenzothiophen-3(2H)-one 1,1-dioxide synthesis

Yield:1240288-81-6 100%

Reaction Conditions:

with sodium hydride in tetrahydrofuran at 20; for 1.5 h;

References:

Crosignani, Stefano;Prêtre, Adeline;Jorand-Lebrun, Catherine;Fraboulet, Ga?le;Seenisamy, Jeyaprakashnarayanan;Augustine, John Kallikat;Missotten, Marc;Humbert, Yves;Cleva, Christophe;Abla, Nada;Daff, Hamina;Schott, Olivier;Schneider, Manfred;Burgat-Charvillon, Fabienne;Rivron, Delphine;Hamernig, Ingrid;Arrighi, Jean-Fran?ois;Gaudet, Marilène;Zimmerli, Simone C.;Juillard, Pierre;Johnson, Zoe [Journal of Medicinal Chemistry,2011,vol. 54,# 20,p. 7299 - 7317] Location in patent:supporting information; experimental part