6-Chloro-2,4-diMethylnicotinic acid synthesis

10synthesis methods

Product Name:6-Chloro-2,4-diMethylnicotinic acid
CAS Number:630082-81-4
Molecular formula:C8H8ClNO2
Molecular Weight:185.61

54453-94-0 Synthesis

54453-94-0
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630082-81-4
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Yield:630082-81-4 88%

Reaction Conditions:

Stage #1: ethyl 6-chloro-2,4-dimethylpyridine-3-carboxylatewith sodium hydroxide;water in ethanol at 90; for 1 h;
Stage #2: with hydrogenchloride in ethanol;water;

Steps:

To a solution of 6-chloro-2,4-dimethyl-nicotinic acid ethyl ester (0.200 g, 0.930 mmol) in EtOH (1 mL) was added 4N NaOH (1 mL), and the mixture was heated at 90° C. for 1 h. After the mixture was cooled to room temperature EtOH was removed and the aqueous residue was acidified with 4N HCl to afford a white precipitate. The precipitate (0.152 g, 88%) was collected by filtration and dried under vacuum to give 6-chloro-2,4-dimethyl-nicotinic acid as a white solid. ¹H NMR (CD₃OD) δ 2.37 (s, 3H), 2.51 (s, 3H), 7.23 (s, 1H)

References:

US2005/277668,2005,A1 Location in patent:Page/Page column 16

1256789-09-9 Synthesis