6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine synthesis

5synthesis methods

Product Name:6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine
CAS Number:38136-96-8
Molecular formula:C5H5ClN4O2S
Molecular Weight:220.64

4,6-Dichloro-2-Methylsulfanyl-5-nitro-pyriMidine

1979-96-0
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6-Chloro-2-(methylthio)-5-nitropyrimidin-4-amine

38136-96-8
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Yield:38136-96-8 100%

Reaction Conditions:

with ammonia;triethylamine in tetrahydrofuran;isopropanol at 20;Cooling;

Steps:

8 Synthesis of intermediate I-2

A solution of NH₃ 2M in iPrOH (1 15 mL, 229.31 mmol) was added drop wise to a solution of H-2 (36.7 g, 152.87 mmol) and Et₃N (23.4 mL, 168.16 mmol) in THF (360 mL) (the temperature was maintained at RT with an ice-water bath during the addition). The reaction mixture was stirred at RT for 5h. The mixture was evaporated to dryness. Water and EtOAc were added to the residue. The layers were separated and the aqueous layer was extracted with EtOAc (twice). The combined organic layers were dried over MgS0₄, filtered, and the solvent was removed under reduced pressure to give 34.5 g (100% yield) of intermediate I-2.

References:

WO2013/68438,2013,A1 Location in patent:Page/Page column 30

1979-96-0
87 suppliers
$19.00/250mg