6-Chloro-3-hydroxy-2-nitropyridine synthesis

Yield: 78%

Reaction Conditions:

with sulfuric acid;potassium nitrate at 0 - 20; for 16 h;

Steps:

15.1 Step 1: Preparation of 6-chloro-2-nitropyridin-3-ol
Potassium nitrate (14g, 138.4mmol) was added in several portions to a mixture of 2- chloropyridin-5-ol (lOg, 77.2mmol) in concentrated sulphuric acid (50ml) at 0°C and further stirred at room temperature for 16h. After the completion of reaction, reaction mixture was poured over crushed ice and the solid was filtered and dried to get the tittle compound (10.5g, 78%). LCMS: m/z = 173.3 (M+1) ⁺.

References:

AURIGENE DISCOVERY TECHNOLOGIES LIMITED;GUMMADI, Venkateshwar Rao;SAMAJDAR, Susanta;MUKHERJEE, Subhendu;BOCK, Mark Gary WO2017/9806, 2017, A1 Location in patent:Page/Page column 76