6-chloro-3-hydroxypyrazine-2-carbonitrile synthesis

4synthesis methods

Product Name:6-chloro-3-hydroxypyrazine-2-carbonitrile
CAS Number:1374986-27-2
Molecular formula:C5H2ClN3O
Molecular Weight:155.54

METHYL 5-CHLOROISOXAZOLO[4,5-B]PYRAZINE-3-CARBOXYLATE

1374986-05-6
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6-chloro-3-hydroxypyrazine-2-carbonitrile

1374986-27-2
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Yield:1374986-27-2 95.9%

Reaction Conditions:

with water;sodium hydroxide in tetrahydrofuran at 80; for 1 h;

Steps:

29 Synthesis Example 29 Synthesis of (A-21)

1.00 mL of tetrahydrofuran, 1.00 mL of water and 20.0 mg (0.491 mmol) of sodium hydroxide were added to 100 mg (0.468 mmol) of the (G-1), and while stirring, the obtained mixture was heated at 80° C. for 1 hour. Thereafter, the reaction solution was cooled to room temperature, and ion exchange resin DOWEX (registered trademark) 50W×2-200 (H) was added thereto. Thereafter, the resultant was filtrated and concentrated, so as to obtain 70.0 mg of (A-21) in the form of a yellow solid. Yield: 95.9%.

References:

US2013/245264,2013,A1 Location in patent:Paragraph 0172

356783-16-9 Synthesis

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References

1374986-03-4
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References

METHYL 5-HYDROXYISOXAZOLO[4,5-B]PYRAZINE-3-CARBOXYLATE

1374986-04-5
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$652.00/1g

1374986-27-2
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References