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ChemicalBook CAS DataBase List 6-Chloro-5-Methyl 1H-indole

6-Chloro-5-Methyl 1H-indole synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 3 steps
1: NaH / dimethylformamide / 0 °C
2: TiCl4 / toluene / 2 h
3: aq. NaOH / ethanol / 0.5 h / Heating

References:

Bromidge, Steven M.;Dabbs, Steven;Davies, David T.;Duckworth, D. Malcolm;Forbes, Ian T.;Ham, Peter;Jones, Graham E.;King, Frank D.;Saunders, Damian V.;Starr, Susannah;Thewlis, Kevin M.;Wyman, Paul A.;Blaney, Frank E.;Naylor, Christopher B.;Bailey, Fiona;Blackburn, Thomas P.;Holland, Vicky;Kennett, Guy A.;Riley, Graham J.;Wood, Martyn D. [Journal of Medicinal Chemistry,1998,vol. 41,# 10,p. 1598 - 1612]