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6-chloro-5-Methylpyridine-3-sulfonyl chloride synthesis

2synthesis methods
-

Yield:37105-10-5 65.3%

Reaction Conditions:

Stage #1: 5-Amino-2-chloro-3-methylpyridinewith hydrogenchloride;NaNO2 in lithium hydroxide monohydrate at 0; for 0.7 h;
Stage #2: with hydrogenchloride;Cupric sulfate;sodium hydrogen sulphite in lithium hydroxide monohydrate at 0 - 5;

References:

WO2022/443,2022,A1 Location in patent:Paragraph 0295