6-Chlorothiazolo[4,5-b]pyridine-2-thiol synthesis
- Product Name:6-Chlorothiazolo[4,5-b]pyridine-2-thiol
- CAS Number:488742-54-7
- Molecular formula:C6H3ClN2S2
- Molecular Weight:202.68
26163-03-1
316 suppliers
$6.00/5g
488742-54-7
15 suppliers
$106.00/1g
Yield:488742-54-7 98%
Reaction Conditions:
with acetic acid in 1-methyl-pyrrolidin-2-one;water;
Steps:
1 1.2 6-Chloro-2-mercaptothiazolo[4,5-b]pyridine
1.2 6-Chloro-2-mercaptothiazolo[4,5-b]pyridine A solution of 133 g (0.64 mol) of 2-amino-3-bromo-5-chloropyridine from Example 1.1 in 1.02 1 of N-methylpyrrolidone was admixed with 205 g (1.28 mol) O-ethylxanthic acid potassium salt. The reaction mixture was refluxed for 6 h and then allowed to cool to ambient temperature. 2.7 l of demineralized water were added then acetic acid to adjust the reaction mixture to pH 4.5. The resulting precipitate was filtered, washed with demineralized water (2*600 ml). The solid was triturated in succession with demineralized water (2*4.2 l) and ethanol, (1.5 l), filtered, washed with ethanol (2*300 ml) followed by hexane (2*400 ml) and dried in vacuo at 45° C. to give 127 g (yield: 98%) of 6-chloro-2-mercaptothiazolo[4,5-b]pyridine used without further purification.
References:
US2003/83311,2003,A1
4214-74-8
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140-89-6
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$12.00/5g
488742-54-7
15 suppliers
$106.00/1g
504-29-0
542 suppliers
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488742-54-7
15 suppliers
$106.00/1g