6-cyclopentyl-o-cresol synthesis
- Product Name:6-cyclopentyl-o-cresol
- CAS Number:1596-19-6
- Molecular formula:C12H16O
- Molecular Weight:176.25
Yield:-
Reaction Conditions:
with boron trifluoride in pentane;
Steps:
2.a a)
a) Preparation of 2-cyclopentyl-6-methylphenol 170 ml of boron trifluoride/phosphoric acid adduct are added to 1.08 kg (10 moles) of o-cresol in 400 ml of pentane. 680 g (10 moles) of cyclopentene, dissolved in 1 l of pentane, are added dropwise at the reflux temperature in the course of 3 hours. The mixture is stirred for a further hour at the reflux temperature and then poured into ice water. The organic phase is separated off and is extracted with 4 times 600 ml of 10% strength sodium hydroxide solution. The organic phase is dried and evaporated down and the residue is distilled (84°-88° C./0.2 mbar).
References:
US5151548,1992,A
