6-Ethoxypyridine-2-carboxylic acid synthesis
- Product Name:6-Ethoxypyridine-2-carboxylic acid
- CAS Number:42955-22-6
- Molecular formula:C8H9NO3
- Molecular Weight:167.16
890655-74-0
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42955-22-6
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Yield:42955-22-6 100%
Reaction Conditions:
with ethanol;sodium hydroxide at 20; for 3 h;Reagent/catalyst;Temperature;
Steps:
1.A; 8.B Step B: 6-ethoxypicolinic acid
To a solution of ethyl 6-ethoxypicolinate (2.6 g, 13.3 mmol, 1 equiv) in EtOH (30 mL) was added sodium hydroxide solution (1 mol/L, 40 mL, 40 mmol, 3 equiv). The reaction mixture was stirred at room temperature for 3 h. The reaction mixture was diluted with 1 N HC1 solution and ethyl acetate. The organic layer was separated and dried over anhydrous MgS04. The filtrate was concentrated in vacuo to afford the title compound 6- ethoxypicolinic acid as a white solid (2.2 g, 100% yield). LC-MS: m/z 168.0 (M+H)+
References:
WO2019/169193,2019,A1 Location in patent:Page/Page column 81-82; 98-99
19621-92-2
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42955-22-6
47 suppliers
$147.00/1g