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6-ETHYL-2,3-DIHYDROQUINOLIN-4(1H)-ONE synthesis

3synthesis methods
-

Yield:-

Steps:

Multi-step reaction with 2 steps
1: 59 percent / acetonitrile / 4 h / Heating
2: 76 percent / phosphorus pentoxide; polyphosphoric acid / 2 h / 100 °C

References:

Jarvest, Richard L.;Hibbs, Martin J.;Jaworski, Deborah D.;O'Hanlon, Peter J.;Pope, Andrew J.;Rittenhouse, Stephen;Sheppard, Robert J.;Slater-Radosti, Courtney;Worby, Angela;Berge, John M.;Berry, Valerie;Boyd, Helen F.;Brown, Murray J.;Elder, John S.;Forrest, Andrew K.;Fosberry, Andrew P.;Gentry, Daniel R. [Journal of Medicinal Chemistry,2002,vol. 45,# 10,p. 1959 - 1962]