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6-FLUOROCHROMAN-8-OL synthesis

4synthesis methods
66892-34-0 Synthesis
6-Fluoro-4-chromanone

66892-34-0
209 suppliers
$10.00/1g

6-FLUOROCHROMAN-8-OL

188826-25-7
5 suppliers
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Yield:-

Steps:

Multi-step reaction with 3 steps
1: H2, AcOH / Pd/C / 760 Torr / Ambient temperature
2: 98 percent / AlCl3 / 1,2-dichloro-ethane / 1 h / -10 °C
3: 1.) m-chloroperbenzoic acid, trifluoroacetic acid, 2.) aq. NaOH / 1.) CH2Cl2, RT, 14 h, 2.) MeOH, RT, 1 h

References:

Yasunaga, Tomoyuki;Naito, Ryo;Kontani, Toru;Tsukamoto, Shin-Ichi;Nomura, Tamako;Yamaguchi, Tokio;Mase, Toshiyasu [Journal of Medicinal Chemistry,1997,vol. 40,# 8,p. 1252 - 1257]