6-FLUOROCHROMONE-3-CARBOXYLIC ACID 97 synthesis
- Product Name:6-FLUOROCHROMONE-3-CARBOXYLIC ACID 97
- CAS Number:71346-17-3
- Molecular formula:C10H5FO4
- Molecular Weight:208.14
69155-76-6
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$16.00/250mg
71346-17-3
32 suppliers
$32.00/1g
Yield:71346-17-3 57%
Reaction Conditions:
with sodium chlorite;aminosulfonic acid in dichloromethane;water at 0 - 25;
Steps:
3.3 General synthesis of 4-oxo-4H-chromene-3-carboxylic acid analogues
General procedure: A solution of sodium chlorite (47.87 mmol) in water (8 mL) was stirred at 0 °C for 10 min. To this solution, 4-oxo-4H-chromene-3-carbaldehyde 2 (13.67 mmol) and sulfamic acid (54.69 mmol) were added, followed by gradual addition of DCM (15 mL). The resulting mixture was stirred for 3 h at room temperature and then quenched with water (25 mL), and extracted with DCM (3 x 25 mL). The combined organic phases were dried over Na2SO4 and concentrated under reduced pressure. The solid obtained was recrystallized from 80:20 methanol-water to give 4-oxo-4H-chromene-3-carboxylic acids 3a-f.
References:
Gordon, Allen T.;Ramaite, Isaiah D.I.;Mnyakeni-Moleele, Simon S. [Arkivoc,2020,vol. 2020,# 5,p. 148 - 160]
394-32-1
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$9.00/5g
71346-17-3
32 suppliers
$32.00/1g