6-fluoroiMidazo[1,2-a]pyridine-2-carbaldehyde synthesis

Yield:881841-32-3 20%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane; for 1 h;Heating / reflux;

Steps:

6.b

Step (b) 6-fluoroimidazo[l,2-a]pyridine-2-carbaldehyde.; 6-fluoroimidazo[l,2-a]pyridin-2-yl)methanol was dissoved in DCM (20 ml) and manganese dioxide (5 g, 57 mmol) added and the reaction mixture heated at reflux for Ih. Mixture cooled to room temperature and filtered through celite, the filtrate evaporated and the residue purified by flash chromatography on silica using hexane:ethyl acetate (3:1) as eluent to afford the sub-title compound (170 mg, 20%).¹HNMR (300 MHz, DMSO-^₅): δ 10.03 (s, IH), 8.84 (dd, IH), 8.61 (d, IH), 7.67 - 7.92 (m, IH), 7.35 - 7.62 (m, IH)

References:

WO2008/84236,2008,A1 Location in patent:Page/Page column 38