6-FLUOROQUINAZOLIN-4-ONE synthesis
- Product Name:6-FLUOROQUINAZOLIN-4-ONE
- CAS Number:16499-56-2
- Molecular formula:C8H5FN2O
- Molecular Weight:164.14
446-08-2
385 suppliers
$14.00/5g
16499-56-2
105 suppliers
$12.00/250mg
Yield: 78%
Reaction Conditions:
with formamide in water
Steps:
3 EXAMPLE 3
A mixture of 2-amino-5-fluorobenzoic acid (2.07 g) and formamide (4 ml) was heated at 160° C. for 2 hours, and for a further 2 hours at 180° C. The reaction mixture was allowed to cool and water was added. The reaction product was filtered off and washed with water and with diethyl ether to give 6-fluoro-3,4-dihydroquinazolin-4-one in 78% yield: m.p. 269-271° C.; Elemental Analysis: Found C, 58.2; H, 3.0; N, 16.9; C8 H4 N2 OF requires C, 58.9; H, 2.5; N, 17.2%.
References:
Zeneca Limited US5955464, 1999, A
67-56-1
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$7.29/5ml-f
63069-49-8
124 suppliers
$15.19/250mg
16499-56-2
105 suppliers
$12.00/250mg
63069-49-8
124 suppliers
$15.19/250mg
149-73-5
518 suppliers
$12.00/5g
16499-56-2
105 suppliers
$12.00/250mg
446-08-2
385 suppliers
$14.00/5g
6313-33-3
190 suppliers
$9.00/1g
16499-56-2
105 suppliers
$12.00/250mg
63069-49-8
124 suppliers
$15.19/250mg
67-68-5
1212 suppliers
$15.00/100g
16499-56-2
105 suppliers
$12.00/250mg