ChemicalBook CAS DataBase List 6-FLUOROQUINOLINE-4-CARBOXYLIC ACID

6-FLUOROQUINOLINE-4-CARBOXYLIC ACID synthesis

4synthesis methods

Product Name:6-FLUOROQUINOLINE-4-CARBOXYLIC ACID
CAS Number:220844-73-5
Molecular formula:C10H6FNO2
Molecular Weight:191.16

Ethanamine, N-[(3,5-dichlorophenyl)methylene]-2,2-diethoxy-

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Yield: 98%

Reaction Conditions:

in water at 200; for 3 h;Sealed tube;

Steps:

53 Synthesis of 6-fluoroquinoline-4-carboxylic acid (53B)
53A (0.30g, 1.28mmol) was dissolved in water (8mL), the tube was sealed at 200°C for 3h, the pH was adjusted to 3-4 with dilute hydrochloric acid, and then filtered with suction to obtain 0.24g of dark brown solid with a yield of 98%.

References:

CN113061098, 2021, A Location in patent:Paragraph 0417; 0418; 0421; 0422

443-69-6 Synthesis