6-IODO-1,1,1,2,2-PENTAFLUOROHEXANE synthesis
- Product Name:6-IODO-1,1,1,2,2-PENTAFLUOROHEXANE
- CAS Number:344452-10-4
- Molecular formula:C6H8F5I
- Molecular Weight:302.02
344452-09-1
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344452-10-4
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$64.00/1g
Yield:344452-10-4 83%
Reaction Conditions:
with sodium iodide in water;acetone;
Steps:
2 Synthesis of 1-Iodo-5,5,6,6,6-pentafluorohexane
Sodium iodide (168 g, 1.12 mol) was added to a solution of 1-methanesulfonyloxy-5,5,6,6,6-pentafluorohexane (101 g, 373.77 mmol) in acetone (2000 ml), followed by heating under reflux for 12 hours. Water was added to the reaction mixture, which was then extracted twice with ether. The combined organic layers were washed with 1% aqueous sodium thiosulfate and saturated aqueous sodium chloride, and then dried over anhydrous magnesium sulfate. After distilling off the solvent, the residue was purified by silica gel column chromatography (eluent: pentane) to give 1-iodo-5,5,6,6,6-pentafluorohexane (93.6 g, Yield 83%). 1H-NMR (300 MHz, CDCl3): δ 3.20 (t, 2H, J=6.9 Hz), 2.27-1.87 (m, 4H), 1.78-1.69 (m, 2H).
References:
US6552068,2003,B1