6-methoxy-2,3-dihydro-1H-quinolin-4-one synthesis

9synthesis methods

Product Name:6-methoxy-2,3-dihydro-1H-quinolin-4-one
CAS Number:3835-21-0
Molecular formula:C10H11NO2
Molecular Weight:177.2

4(1H)-Quinolinone, 2,3-dihydro-6-methoxy-1-[(4-methylphenyl)sulfonyl]-

75227-41-7
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3835-21-0
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Yield:3835-21-0 90.9%

Reaction Conditions:

with hydrogenchloride;acetic acid in water at 80; for 8 h;

Steps:

1.4 Preparation of 6-methoxy-2,3-dihydro-4(1H)-quinolinone

N-p-toluenesulfonyl-6-methoxy-2,3-dihydro-quinolinone 24.8g (74.8mmol) was added three 250ml bottle, then concentrated hydrochloric acid was added with good: acetic acid: water = 2: 2:1 (V / V / V) mixture of 125ml, 80 ° C reaction 8h, reaction completion, -0.06 ~ -0.01Mpa reaction mixture was evaporated to 1/4 of the original solution, potassium hydroxide solution was adjusted pH with saturated hydrogen 10, filtration, and dried to give a yellow solid 12.1g, yield: 90.9%.

References:

CN103772276,2016,B Location in patent:Paragraph 0049; 0060-0061

4(1H)-Quinolinone, 2,3-dihydro-6-methoxy-1-(phenylmethyl)-

890841-64-2
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3835-21-0
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References

7661-29-2
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References

β-Alanine, N-(4-methoxyphenyl)-N-[(4-methylphenyl)sulfonyl]-

6945-33-1
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3835-21-0
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References

104-94-9 Synthesis

104-94-9
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3835-21-0
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References