6-Methoxy-iMidazo[1,2-b]pyridazine synthesis
- Product Name:6-Methoxy-iMidazo[1,2-b]pyridazine
- CAS Number:17240-33-4
- Molecular formula:C7H7N3O
- Molecular Weight:149.15
67-56-1
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$9.00/25ml
124-41-4
709 suppliers
$12.00/25g
![6-Chloroimidazo[2,1-f]pyridazine](/CAS/GIF/6775-78-6.gif)
6775-78-6
279 suppliers
$6.00/1g
17240-33-4
15 suppliers
$65.00/50mg
Yield:17240-33-4 91%
Reaction Conditions:
at 20; for 18 h;
Steps:
10.1 Step 1: 6-Methoxyimidazo[1,2-b]pyridazine 46
Sodium methoxide (7.35 eq., 7.76g, 143.6 mmol) was added to a solution of 6-chloroimidazo[1 ,2-bb]pyridazine ( 3.0 g, 19.54 mmol) in anhydrous methanol (8 ml) at ambient temperature and the reaction mixture stirred for 18 hours. The volatiles were removed by evaporation and the yellow oily residue was dissolved in dichloromethane (100 ml). The solution was washed with water (5x100 ml) until aqueous wash became neutral. The organic solution was dried (MgSC ) and the solvent removed. The title compound (m = 8.87 g, yield = 91%) was obtained as a white solid. 1H NMR (400 MHz, DMSO -cfe) d 7.36 (d, J = 9.3 Hz , 1 H), 6.85 (d, J = 9.3 Hz, 1 H), 6.61 (s, 1 H)13C NMR (101 MHz, CDCIs) d 160.2, 137.3, 132.4, 127.3, 116.8, 112.1 , 54.4
References:
WO2021/23858,2021,A1 Location in patent:Page/Page column 68-69
124-41-4
709 suppliers
$12.00/25g
6775-78-6
279 suppliers
$6.00/1g
17240-33-4
15 suppliers
$65.00/50mg