(6-Methyl-1H-benzimidazol-2-yl)methanol synthesis

Yield:20034-02-0 100%

Reaction Conditions:

with hydrogenchloride in water; for 3 h;Reflux;

Steps:

((5-Methyl-1H-benzimidazole-2-yl)-methanol) 25

(5-Methyl-1H-benzimidazole-2-yl)-methanol 25 was prepared using the Phillips procedure [1], 4-Methyl-1,2-phenylenediamine (12.22 g; 0.1 mol) and glycolic acid (11.40 g; 0.15 mmol) in hydrochloric acid (50 ml, 5.5 M) were heated under reflux with for 3 h. The reaction mixture was cooled to room temperature and ammonia solution was added and the mixture cooled in ice until a bright brown precipitate formed. The resulting solid was recrystallised from aqueous ethanol to give (5-methyl-1H-benzimidazole-2-yl)-methanol as a pale creamy powdery solid Yield 100%.

References:

Alasmary, Fatmah A.S.;Snelling, Anna M.;Zain, Mohammed E.;Alafeefy, Ahmed M.;Awaad, Amani S.;Karodia, Nazira [Molecules,2015,vol. 20,# 8,p. 15206 - 15223] Location in patent:supporting information