6-Methylquinoline-8-carboxylic acid synthesis

4synthesis methods

Product Name:6-Methylquinoline-8-carboxylic acid
CAS Number:55706-57-5
Molecular formula:C11H9NO2
Molecular Weight:187.19

84839-95-2
59 suppliers
$68.00/50mg

124-38-9
122 suppliers
$214.00/14L

55706-57-5
30 suppliers
$144.00/100mg

Yield:55706-57-5 79%

Reaction Conditions:

Stage #1: 6-methyl-8-bromoquinolinewith tert.-butyl lithium in diethyl ether;pentane at -78; for 0.5 h;Inert atmosphere;
Stage #2: carbon dioxide in diethyl ether;pentane;Inert atmosphere;
Stage #3: with hydrogenchloride in water;Inert atmosphere;

References:

Hoang, Giang T.;Walsh, Dylan J.;McGarry, Kathryn A.;Anderson, Constance B.;Douglas, Christopher J. [Journal of Organic Chemistry,2017,vol. 82,# 6,p. 2972 - 2983]

583-68-6 Synthesis