ChemicalBook CAS DataBase List 6-NITRO-1,3-BENZODIOXOL-5-AMINE

6-NITRO-1,3-BENZODIOXOL-5-AMINE synthesis

5synthesis methods

Product Name:6-NITRO-1,3-BENZODIOXOL-5-AMINE
CAS Number:64993-07-3
Molecular formula:C7H6N2O4
Molecular Weight:182.13

N-(6-Nitro-1,3-benzodioxol-5-yl)acetamide

81864-14-4
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64993-07-3
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Yield:64993-07-3 97%

Reaction Conditions:

with sodium ethanolate in methanol; for 0.25 h;Reflux;

Steps:

1.6.4 (4) 6-nitrobenzo[d][1,3]dioxol-5-amine (6-Nitrobenzo[d][1,3]dioxol-5-amine; 11H)

NaOEt (193 mg, 2.84 mmol) was added into a solution in which compound 10H (200 mg, 0.89 mmol) was dissolved in methanol (4 mL) and stirred at reflux for 15 minutes.After cooling, acetic acid (1.0 mL) was added to the reaction mixture, and the residue obtained by concentration under reduced pressure was purified by silica gel column chromatography (hexane: ethyl acetate = 5: 1) to obtain Compound 11H (159 mg, 97%) as an orange solid. Got.

References:

KR2020/11270,2020,A Location in patent:Paragraph 0086; 0292; 0294; 0304-0306