6-Nitrobenzo[b]thiophene-2-carboxylic acid synthesis
- Product Name:6-Nitrobenzo[b]thiophene-2-carboxylic acid
- CAS Number:19983-42-7
- Molecular formula:C9H5NO4S
- Molecular Weight:223.21
34084-88-3
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Yield:19983-42-7 153 mg
Reaction Conditions:
with lithium hydroxide monohydrate in methanol;water at 80; for 2 h;
Steps:
11
A mixture of 180 mg of methyl 6-nitrobenzo[b]thiophene-2-carboxylate, 48 mg of lithium hydroxide monohydrate,2 ml of water, and 4 ml of methanol was stirred for 2 hours at 80°C. After the reaction mixture was cooled to roomtemperature, 10 ml of 0.5 M aqueous hydrochloric acid solution was added thereto. The precipitated solids were collectedby filtration and dried under reduced pressure, thereby obtaining 153 mg of 6-nitrobenzo[b]thiophene-2-carboxylic acid(hereinafter, described as a "compound 19 of the present invention").1H-NMR (DMSO-D6) δ: 13.93 (br s, 1H), 9.14 (s, 1H), 8.26-8.22 (m, 3H).
References:
EP2926660,2015,A1 Location in patent:Paragraph 0274; 0275
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19983-42-7
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