6-nitroquinoline-2-carbonitrile synthesis
- Product Name:6-nitroquinoline-2-carbonitrile
- CAS Number:13675-93-9
- Molecular formula:C10H5N3O2
- Molecular Weight:199.17
Yield:13675-93-9 93%
Reaction Conditions:
with tetrachloromethane;phosphonic acid diethyl ester;potassium hydroxide in 1,4-dioxane at 20; for 4 h;
Steps:
7 A method for synthesizing 6-nitro-2-cyanoquinoline includes the following steps:
6-nitro-quinoline-N-oxide (0.190 g, 1 mmol), trimethylcyanosilane (0.119 g, 1.2 mmol), diethyl H-phosphite (0.276 g, 2 mmol), carbon tetrachloride (0.308 g, 2 mmol), KOH (0.112 g, 2 mmol), 10 mL of dioxane in a 50 mL three-necked flask, and reacted at room temperature for 4 h. After the reaction was completed, the solvent was removed under reduced pressure and separated by column chromatography (petroleum Ether / ethyl acetate, V / V = 5: 1) to obtain the target compound as a yellow powder with a yield of 93% and the structural formula is as follows:
References:
CN110256342,2019,A Location in patent:Paragraph 0054-0058
613-30-9
106 suppliers
$65.00/1g
13675-93-9
0 suppliers
inquiry
613-50-3
234 suppliers
$10.00/5g
13675-93-9
0 suppliers
inquiry