6-Oxooctanoic acid ethyl ester synthesis

5synthesis methods

Product Name:6-Oxooctanoic acid ethyl ester
CAS Number:4233-58-3
Molecular formula:C10H18O3
Molecular Weight:186.25

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Yield:4233-58-3 51%

Reaction Conditions:

with iron(III) chloride in acetonitrile at 20; for 36 h;Glovebox;Inert atmosphere;Irradiation;

Steps:

Standard Reaction Conditions

General procedure: A) To an oven-dried 1.5 dram vial was added FeCl3 (25 mol%). Any solid reactants were also added at this stage. Amagnetic stir bar was added and the vial was transferred to a glovebox. Anhydrous acetonitrile (1 mL, 0.3 M) wasthen added, followed by the C-H substrate (5 equiv.) and the electron-deficient alkene (1 equiv.). The vial was sealedand then placed on a stir plate 2-3 inches away from a 390 nm Kessil lamp. Ambient temperature was maintained withthe use of a fan above the set-up. After 36 hours, the reaction mixture was concentrated in vacuo and purified usingsilica gel flash column chromatography, using ethyl acetate/hexanes as the eluent.

References:

Kang, Yi Cheng;Rovis, Tomislav;Treacy, Sean M. [Synlett,2021,vol. 32,# 17,p. 1767 - 1771] Location in patent:supporting information

64-17-5 Synthesis