ChemicalBook CAS DataBase List 6-P-TOLYLPYRIDIN-3-YLAMINE

6-P-TOLYLPYRIDIN-3-YLAMINE synthesis

6synthesis methods

Product Name:6-P-TOLYLPYRIDIN-3-YLAMINE
CAS Number:170850-45-0
Molecular formula:C12H12N2
Molecular Weight:184.24

131941-26-9
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170850-45-0
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Yield: 99%

Reaction Conditions:

with nickel in ethanol;ethyl acetate at 65;

Steps:

3.2 General procedure for the nitro group reduction
General procedure: 4.3.1 4'-Methyl-4-aminobiphenyl (4a) Compound 3a (2.54 mmol, 541 mg) was dissolved in an EtOH/EtOAc 1:1 mixture (50 mL) and reduced by hydrogenation catalysed by Raney Nickel in an H-Cube at 65 °C at a flow rate of 0.8 mL/min, using full hydrogen mode. The solution obtained was concentrated under reduced pressure to give 480 mg of a yellow solid, which was purified by chromatography on silica gel, hexane/CH₂Cl₂ 1:1, to give 440 mg of the pure expected product as an off-white solid (95% yield).

References:

Baltus, Christine B.;Press, Neil J.;Antonijevic, Milan D.;Tizzard, Graham J.;Coles, Simon J.;Spencer, John [Tetrahedron,2012,vol. 68,# 45,p. 9272 - 9277]

13534-97-9 Synthesis