6-PHENOXY-3-PYRIDINESULFONYL CHLORIDE synthesis

Yield:1263277-41-3 94%

Reaction Conditions:

with ammonia in water;acetonitrile at 0 - 20; for 0.5 h;

Steps:

4.1.43 General procedure for the synthesis of sulfonamides 52 and 53

General procedure: To a cooled (0 °C) solution of sulfonyl chloride 50 or 51 (4.12 mmol) in CH₃CN (0.4 mL), a solution of aqueous ammonia (1.32 mL) was added dropwise. The reaction was stirred at RT for 30 min, and then it was diluted with water and extracted with EtOAc. Organic layers were dried over Na₂SO₄ and concentrated in vacuo to give the desired sulfonamides.

References:

Nuti, Elisa;Santamaria, Salvatore;Casalini, Francesca;Yamamoto, Kazuhiro;Marinelli, Luciana;La Pietra, Valeria;Novellino, Ettore;Orlandini, Elisabetta;Nencetti, Susanna;Marini, Anna Maria;Salerno, Silvia;Taliani, Sabrina;Da Settimo, Federico;Nagase, Hideaki;Rossello, Armando [European Journal of Medicinal Chemistry,2013,vol. 62,p. 379 - 394]