ChemicalBook CAS DataBase List 6-PIPERAZINONICOTINONITRILE

6-PIPERAZINONICOTINONITRILE synthesis

3synthesis methods

Product Name:6-PIPERAZINONICOTINONITRILE
CAS Number:149554-29-0
Molecular formula:C10H12N4
Molecular Weight:188.23

110-85-0 Synthesis

110-85-0
551 suppliers
$5.00/5 g

33252-28-7 Synthesis

33252-28-7
431 suppliers
$6.00/1g

149554-29-0
76 suppliers
$14.50/1g

Yield:-

Reaction Conditions:

in acetonitrile at 60; for 5 h;

Steps:

48A
Example 48 6-(4-f4-rf3aR,6aR)-5-methvihexahvdropyrrolof3,4-biPyrrol-1 f2HV vl]ρhenyl)piperazin-1~yl)nicotinonitrile Example 48A β-Piperazin-1-yl-nicotinonilrile6-Chlorαnicotinonitrile (500 mg, 3.61 mmole) and piperazine (930 mg, 10.8 mmole) were dissolved in 20 m. of acetonitrile and heated at 60 ⁰C under N₂ for 5 hours. The mixture was cooled to room temperature, diluted with water and extracted with dichloromethane (5x), The combined organics were dried over sodium sulfate, filtered, and concentrated to provide the title compound. ¹H NMR (300 MHz, CDCl₃) δ 8,40 (d, J=1.70 Hz, 1 H) 7.60 (dd, J=8.81 , 2.37 Hz, 1 H) 6.59 (d, J=8.48 Hz, 1 H) 3.57 - 375 (m, 4 H) 2.91 - 3.05 += 189

References:

ABBOTT LABORATORIES WO2007/100990, 2007, A2 Location in patent:Page/Page column 93-94

683274-61-5 Synthesis

5-CYANO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE

683274-61-5
18 suppliers
inquiry

149554-29-0
76 suppliers
$14.50/1g

References

33252-28-7 Synthesis

33252-28-7
431 suppliers
$6.00/1g

149554-29-0
76 suppliers
$14.50/1g

References

6-PIPERAZINONICOTINONITRILE Related Search:

5-CYANO-2-[4-BUTOXYCARBONYL(PIPERAZINO)]PYRIDINE 6-(4-METHYLPIPERAZIN-1-YL)NICOTINONITRILE