ChemicalBook CAS DataBase List 4H-Cyclopenta-1,3-dioxol-4-one, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, (3aR,6R,6aR)-

4H-Cyclopenta-1,3-dioxol-4-one, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, (3aR,6R,6aR)- synthesis

7synthesis methods

Product Name:4H-Cyclopenta-1,3-dioxol-4-one, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, (3aR,6R,6aR)-
CAS Number:145307-55-7
Molecular formula:C15H28O4Si
Molecular Weight:300.47

(3aR,6R,6aR)-6-(Hydroxymethyl)-2,2-dimethyldihydro-3ah-cyclopenta[d][1,3]dioxol-4(5H)-one

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18162-48-6 Synthesis

18162-48-6
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4H-Cyclopenta-1,3-dioxol-4-one, 6-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]tetrahydro-2,2-dimethyl-, (3aR,6R,6aR)-

145307-55-7
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$1760.00/1g

Yield:-

Reaction Conditions:

with pyridine at 28; for 6 h;Inert atmosphere;

Steps:

3.2 Step 2: Preparation of compound 3-3

Under nitrogen protection,Compound 3-2 (3.3g, 17.72mmol)Dissolved in pyridine (50mL),Add tert-butyldimethylchlorosilane (4.01g, 26.58mmol, 3.26mL),The reaction mixture was stirred at 28°C for 6h.The reaction was quenched by adding methanol (2mL), concentrated under reduced pressure,The crude product was purified by silica gel column chromatography (petroleum ether/ethyl acetate (v/v) = 5/1) to obtain compound 3-3.

References:

CN111349132,2020,A Location in patent:Paragraph 0292; 0297-0300

115509-13-2 Synthesis