6-(trifluoromethyl)quinolin-2-amine synthesis
- Product Name:6-(trifluoromethyl)quinolin-2-amine
- CAS Number:791595-93-2
- Molecular formula:C10H7F3N2
- Molecular Weight:212.17
78060-56-7
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791595-93-2
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Yield:791595-93-2 38%
Reaction Conditions:
with ammonium hydroxide at 130;
Steps:
31.6 Step 6. Formation of 6-(trifluoromethyl)quinolin-2-amine
0766] A solution of 2-chloro-6-(trifluoromethyl)quinoline (1 g, 4.3 mmol) in ammonium hydroxide (50 ml) was stirred overnight at 130° C. The resulting mixture was then concentrated under vacuum to give a residue, which was purified by silica gel column chromatography using 1%2% methanol in dichloromethane to afford 6-(trifluoromethyl)quinolin-2-amine as an off-white solid (350 mg, 38%). (ES, m/z): [M+H]+ 212; 1H NMR (300 MHz, CDCl3): δ 7.97-7.86 (m, 2H), 7.71 (s, 2H), 6.85 (d, J=9.0 Hz, 1H), 5.26 (s, 2H).
References:
US2014/142114,2014,A1 Location in patent:Paragraph 0765; 0766
455-14-1
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791595-93-2
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835903-14-5
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791595-93-2
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$65.00/5mg