ChemicalBook CAS DataBase List (4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE

(4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE synthesis

4synthesis methods

Product Name:(4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE
CAS Number:60458-71-1
Molecular formula:C8H12N4OS
Molecular Weight:212.27

Acetic acid, 2-[(4,6-dimethyl-2-pyrimidinyl)thio]-, ethyl ester

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(4,6-DIMETHYL-PYRIMIDIN-2-YLSULFANYL)-ACETIC ACID HYDRAZIDE

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Yield:60458-71-1 92%

Reaction Conditions:

with hydrazine hydrate in ethanol;Reflux;

Steps:

1 Embodiment 1 synthesis of derivatives Ia (benzene ring unsubstituted, n= 0)

Ethyl 2 - ((4,6-dimethylpyrimidin-2-yl) thio) acetate was dissolved in absolute ethanol and 85% hydrazine hydrate (10.5 g , 0.213 mol). After the addition, the reaction mixture was heated to reflux, and the reaction was terminated by TLC. The crude product was obtained by washing, suction filtration and drying. 2 - ((4,6- -yl) thio) acetohydrazide as a white solid in 92% yield

References:

CN105585538,2016,A Location in patent:Paragraph 0026

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References

22325-27-5 Synthesis

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123-54-6 Synthesis

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