3-Quinolinemethanamine,2-chloro-8-methyl-N-(phenylmethyl)-(9CI) synthesis
- Product Name:3-Quinolinemethanamine,2-chloro-8-methyl-N-(phenylmethyl)-(9CI)
- CAS Number:606095-53-8
- Molecular formula:C18H17ClN2
- Molecular Weight:296.79
Yield:606095-53-8 63%
Reaction Conditions:
with triethylamine in ethanol;Reflux;
Steps:
4.1.3. General procedure for the synthesis of compounds 4a-p
General procedure: Compound 3 (1.13 g, 0.005 mol) was dissolved in 20 ml of absolute ethanol and to this solution equimolar amount of substituted aniline/butyl/cyclohexyl/benzylamine (0.005 mol) along with 1 ml of triethylamine was added and the mixture was refluxed for 12-16 h. After completion of the reaction (monitored by TLC), the contents of the flask were reduced to one third of its volume and left overnight. The solid mass obtained was filtered, washed with water, dried and recrystallized from ethanol. The physical data of compounds 4a-p is presented in the Table 1
References:
Kumar, Suresh;Bawa, Sandhya;Drabu, Sushma;Gupta, Himanshu;MacHwal, Lalit;Kumar, Rajiv [European Journal of Medicinal Chemistry,2011,vol. 46,# 2,p. 670 - 675] Location in patent:experimental part
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