2-Propenoic acid, 3-[3-(chlorosulfonyl)phenyl]-, Methyl ester, (2E)- synthesis

6synthesis methods

Product Name:2-Propenoic acid, 3-[3-(chlorosulfonyl)phenyl]-, Methyl ester, (2E)-
CAS Number:610801-83-7
Molecular formula:C10H9ClO4S
Molecular Weight:260.69

58186-45-1 Synthesis

58186-45-1
19 suppliers
$243.00/1g

2-Propenoic acid, 3-[3-(chlorosulfonyl)phenyl]-, Methyl ester, (2E)-

610801-83-7
24 suppliers
$348.48/1g

Yield:-

Reaction Conditions:

Stage #1: 3-(3-amino-phenyl)-acrylic acid methyl esterwith hydrogenchloride;glacial acetic acid in lithium hydroxide monohydrate;
Stage #2: with NaNO₂ in lithium hydroxide monohydrate at -13 - -5;
Stage #3: with sulfur(IV) oxide;glacial acetic acid;copper chloride (I) in lithium hydroxide monohydrate at 0;

References:

Yang, Lei;Xue, Xiaowen;Zhang, Yihua [Synthetic Communications,2010,vol. 40,# 17,p. 2520 - 2524] Location in patent:experimental part

100-52-7 Synthesis