tert-Butyl 4-[(2-nitrophenoxy)methyl]piperidine-1-carboxylate synthesis

2synthesis methods

Product Name:tert-Butyl 4-[(2-nitrophenoxy)methyl]piperidine-1-carboxylate
CAS Number:614729-90-7
Molecular formula:C17H24N2O5
Molecular Weight:336.38

tert-Butyl 4-[(2-nitrophenoxy)methyl]piperidine-1-carboxylate

614729-90-7
8 suppliers
$350.00/1g

tert-Butyl 4-[(2-aminophenoxy)methyl]piperidine-1-carboxylate

614730-59-5
7 suppliers
$370.00/1g

Yield:614730-59-5 88%

Steps:

P.143 1-(tert-Butoxycarbonyl) -4-(2-aminophenoxymethyl)piperidine

Production Example 143 1-(tert-Butoxycarbonyl) -4-(2-aminophenoxymethyl)piperidine The title compound (4.28 g, 88% yield) was obtained in the same manner as Production Example 140 from 5.34 g of 1-(tert-butoxycarbonyl)-4-(2-nitrophenoxymethyl)piperidine. 1H-NMR (400 MHz, CDCl₃); δ (ppm) 1.24-1.36 (2H, m), 1.47 (9H, s), 1.79-1.86 (2H, m), 1.94-2.06 (1H, m), 2.68-2.84 (2H, m), 3.77 (2H, br s), 3.85 (2H, d, J=6.0 Hz), 4.06-4.26 (2H, m), 6.68-6.82 (4H, m).

References:

US2004/167224,2004,A1

614729-90-7
8 suppliers
$350.00/1g

4-[(2-Nitrophenoxy)methyl]piperidine hydrochloride

614730-50-6
12 suppliers
$237.00/500mg

References