1-[2-(4-Piperidinylmethoxy)phenyl]-1-ethanonehydrochloride synthesis

Yield:614730-48-2 100%

Steps:

P.132 4-(2-Acetylphenoxymethyl)piperidine hydrochloride

Production Example 132 4-(2-Acetylphenoxymethyl)piperidine hydrochloride The title compound (177 mg, 100% yield) was obtained in the same manner as Production Example 113 from 220 mg of 1-(tert-butoxycarbonyl)-4-(2-acetylphenoxymethyl)piperidine. 1H-NMR (400 MHz, DMSO-d6); δ (ppm) 1.51-1.63 (2H, m), 1.89-1.97 (2H, m), 2.07-2.19 (1H, m), 2.56 (3H, s), 2.85-2.97 (2H, m), 3.26-3.34 (2H, m), 4.00 (2H, d, J=6.0 Hz), 7.02 (1H, dt, J=7.6, 0.8 Hz), 7.17 (1H, d, J=8.0 Hz), 7.50-7.55 (1H, m), 7.57 (1H, dd, J=7.6, 2.0 Hz), 8.50-8.85 (1H, m), 8.94-9.08 (1H, m).

References:

US2004/167224,2004,A1