ChemicalBook CAS DataBase List 2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-6-carbaldehyde

2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-6-carbaldehyde synthesis

7synthesis methods

Product Name:2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-6-carbaldehyde
CAS Number:615568-24-6
Molecular formula:C8H7NO3
Molecular Weight:165.15

615568-23-5 Synthesis

2H,3H-[1,4]dioxino[2,3-b]pyridin-6-ylMethanol

615568-23-5
24 suppliers
$180.00/100mg

2,3-dihydro-[1,4]dioxino[2,3-b]pyridine-6-carbaldehyde

615568-24-6
43 suppliers
$59.00/2mg

Yield:615568-24-6 66%

Reaction Conditions:

with manganese(IV) oxide in dichloromethane at 20; for 15 h;

Steps:

7.d

Alcohol (7c) (145mg, 0.87mmol) was dissolved in dichloromethane (5mL) and treated with manganese dioxide (151mg, 1.74mmol). The resulting slurry was stirred at room temperature and after 5 hours a further batch of manganese dioxide (151 mg, 1.74mmol) was added. The slurry was stirred for a further 10 hours and then filtered through Celite and the volatiles removed in vacuo. The residue was purified on silica gel to afford the desired product (95mg, 66%). MS (APCI+) m/z 166 (MH+).

References:

WO2004/14361,2004,A1 Location in patent:Page/Page column 37

23003-30-7 Synthesis

23003-30-7
126 suppliers
$10.00/100mg

615568-24-6
43 suppliers
$59.00/2mg

References

1,4-Dioxino[2,3-b]pyridine, 2,3-dihydro-6-methyl-, 5-oxide

615568-21-3
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615568-24-6
43 suppliers
$59.00/2mg

References

6-Methyl-2H,3H-[1,4]dioxino[2,3-b]pyridine

129421-33-6
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615568-24-6
43 suppliers
$59.00/2mg

References

2-(2-iodo-6-methyl-pyridin-3-yloxy)-ethanol

443955-66-6
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615568-24-6
43 suppliers
$59.00/2mg

References