![](/CAS/GIF/61563-39-1.gif)
2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride synthesis
- Product Name:2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride
- CAS Number:61563-39-1
- Molecular formula:C11H12ClNO3S
- Molecular Weight:273.74
![1-[3,4-Dihydroisoquinoline-2(1H)-yl]ethanone](/CAS/GIF/14028-67-2.gif)
14028-67-2
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![2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride](/CAS/GIF/61563-39-1.gif)
61563-39-1
17 suppliers
$282.88/250mg
Yield:-
Reaction Conditions:
with chlorosulfonic acid in dichloromethane;
Steps:
1 Preparation of 2-Acetyl-7-Chlorosulfonyl-1,2,3,4,-Tetrahydroisoquinoline
Preparation of 2-Acetyl-7-Chlorosulfonyl-1,2,3,4,-Tetrahydroisoquinoline To a solution of 140 g. (0.8 mole) 2-acetyl-1,2,3,4-tetrahydroisoquinoline in 150 ml. dry methylene chloride at -15° C. with sufficient stirring was added dropwise 300 ml. (4.5 mole) chlorosulfonic acid. After the addition of the chlorosulfonic acid was complete, the reaction mixture was stirred for one hour at -15° C. and then heated to reflux for 2 hours. The reaction mixture was then cooled to 10° C. and then cautiously poured onto 3 l. of ice. The crude reaction product was then extracted in methylene chloride (2*150 ml.), dried over anhydrous magnesium sulfate and filtered. The filtrate was concentrated to dryness at reduced pressure to afford 2-acetyl-7-chlorosulfonyl-1,2,3,4,-tetrahydroisoquinoline as a viscous yellow oil.
References:
US4315935,1982,A
![1,2,3,4-TETRAHYDROISOQUINOLINE](/CAS/GIF/91-21-4.gif)
91-21-4
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![2-acetyl-1,2,3,4-tetrahydroisoquinoline-7-sulfonyl chloride](/CAS/GIF/61563-39-1.gif)
61563-39-1
17 suppliers
$282.88/250mg