1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one synthesis
- Product Name:1-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethan-1-one
- CAS Number:617706-15-7
- Molecular formula:C8H3BrF4O
- Molecular Weight:271.01
1039827-16-1
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617706-15-7
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Yield:617706-15-7 88%
Reaction Conditions:
with Dess-Martin periodane;trifluoroacetic acid in dichloromethane at 20; for 3 h;
Steps:
82.b
b) l-(5-Bromo-2-fluorophenyl)-2,2,2-trifluoroethanone; Beilstein Registry Number 9622366Chemical Formula: C8H3BrF4O Exact Mass: 269.93Molecular Weight. 271.01 [00215] A solution of l-(5-bromo-2-fluorophenyl)-2,2,2-trifluoroethanol (2.26 g, 8.29 mmol) in CH2Cl2 (80 mL) was treated sequentially with Dess-Martin periodinane (5.83 g, 13.75 mmol) and TFA (1 1 mL, 15 mmol). After stirring at room temperature for 3 hours, the mixture was treated with silica gel and concentrated. The adsorbed material was loaded onto a silica gel column and purified (CH2Cl2) to give the title compound (1 99 g, 88%) as a colorless liquid: 1H NMR (500 MHz, CDCl3) δ 7.99 (dd, J= 6.0, 2.5 Hz, IH), 7.78 (ddd, J= 9.0, 4.5, 2.5 Hz, IH), 7 15 (dd, J= 10.0, 9.0 Hz, IH).
References:
WO2008/86404,2008,A1 Location in patent:Page/Page column 126
383-63-1
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460-00-4
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617706-15-7
35 suppliers
$109.00/250mg