ChemicalBook CAS DataBase List 5-(TRIFLUOROMETHYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

5-(TRIFLUOROMETHYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID synthesis

2synthesis methods

Product Name:5-(TRIFLUOROMETHYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID
CAS Number:618070-62-5
Molecular formula:C11H6F4N2O2
Molecular Weight:274.17

ETHYL 2-(4-FLUOROPHENYL)-3-(TRIFLUOROMETHYL)PYRAZOLE-4-CARBOXYLATE

175137-38-9
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5-(TRIFLUOROMETHYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID

618070-62-5
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Yield:-

Reaction Conditions:

with water;sodium hydroxide for 0.5 h;Reflux;

Steps:

2.3 3)Synthesis of 1- (4-fluoro) phenyl-5-trifluoromethyl-4-pyrazolecarboxylic acid

The above 1- (4-fluoro) phenyl-5-trifluoromethyl-4-pyrazolecarboxylic acid ethyl ester was added to a 250 ml three-0.12 mol sodium hydroxide,50ml water,Heated to reflux for 0.5 hours,TLC detection reaction is complete.cool down,Acidified with concentrated hydrochloric acid to pH = 3 or so,A large number of precipitation,Suction filtration,drying,A white solid was obtained,Namely 1- (4-fluoro) phenyl-5-trifluoromethyl-4-pyrazolecarboxylic acid (for the basic structural information, see No. 8 in Table 1)The tested purity (HPLC) was 96.1%.

References:

CN107501182,2017,A Location in patent:Paragraph 0044; 0045

571-55-1 Synthesis

Ethyl 2-(ethoxymethylene)-4,4,4-trifluoroacetoacetate

571-55-1
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618070-62-5
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References

5-(TRIFLUOROMETHYL)-1-(4-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID Related Search:

1-PHENYL-5-(TRIFLUOROMETHYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID 1-(4-FLUOROPHENYL)-5-METHYL-1H-PYRAZOLE-4-CARBOXYLIC ACID