5-AMINO-1-(2-FLUOROPHENYL)-1H-PYRAZOLE-4-CARBOXYLIC ACID synthesis

Yield:-

Reaction Conditions:

with water;sodium hydroxide in ethanol;

References:

Das, Jagabandhu;Moquin, Robert V.;Dyckman, Alaric J.;Li, Tianle;Pitt, Sidney;Zhang, Rosemary;Shen, Ding Ren;McIntyre, Kim W.;Gillooly, Kathleen;Doweyko, Arthur M.;Newitt, John A.;Sack, John S.;Zhang, Hongjian;Kiefer, Susan E.;Kish, Kevin;McKinnon, Murray;Barrish, Joel C.;Dodd, John H.;Schieven, Gary L.;Leftheris, Katerina [Bioorganic and Medicinal Chemistry Letters,2010,vol. 20,# 23,p. 6886 - 6889] Location in patent:scheme or table