ChemicalBook CAS DataBase List 8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)

8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI) synthesis

4synthesis methods

Product Name:8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)
CAS Number:623564-43-2
Molecular formula:C7H8N2O2
Molecular Weight:152.15

2H-1,4-Oxazin-3-amine, 5,6-dihydro-, hydrochloride (1:1)

623564-41-0
2 suppliers
inquiry

623564-42-1 Synthesis

8H-Imidazo[2,1-c][1,4]oxazine-2-carboxaldehyde, 5,6-dihydro- (9CI)

623564-42-1
39 suppliers
$130.00/50mg

8H-Imidazo[2,1-c][1,4]oxazine-3-carboxaldehyde, 5,6-dihydro- (9CI)

623564-43-2
27 suppliers
inquiry

Yield:623564-42-1 36.3% ，623564-43-2 16.1%

Reaction Conditions:

Stage #1: 2-bromo-3-hydroxypropenalwith toluene-4-sulfonic acid;isopropyl alcohol in cyclohexane at 80;
Stage #2: morpholin-3-ylideneamine hydrochloridewith sodium methylate in methanol;ethanol at 20; for 2 h;
Stage #3: with triethylamine in chloroform; for 2 h;Heating / reflux;

Steps:

7.5

Step 5: 5,6-Dihydro-8H-imidazo[2,1-c][1,4]oxazine-2-carbaldehyde (9) and 56- dihvdro-8H-imidazof2, 1-clf1, 410xazine-3-carbaldehYde; The mixture of 2-bromo-3-hydroxypropenal (4.1 g), p-toluenesulfonic acid monohydrate (52 mg) and 2-propanol (5.2 mL) in cyclohexane (42 mL) was azeotroped until the vapor temperature rose to 80°C. The reaction mixture was concentrated under reduce pressure. The residue was dissolved in dry ethanol (50 mL). A mixture of the dry ethanol (200 mL) solution of 3-iminomorpholin hydrochloride (3.4 g) and 28% methanol solution of sodium methylat (4.8 g) was added at room temperature. The reaction mixture was stirred at room temperature for 2 h, and then the reaction solvent was removed in vacuo. The residue was dissolved in chloroform (125 mL) and triethylamine (3.5 mL) was added, then the reaction mixture was heated to reflux for 2 h. The reaction mixture was cooled to room temperature and then concentrated under reduce pressure. The residue was dissolved in dichloromethane (300 mL) and washed with 50% K2CO3 aqueous solution (2 x 100 mL). The organic layer was dried (MgS04) and filtered. The filtrate was concentrated under reduce pressure. The residue was applied to silica gel column chromatography and eluted with CHCI3-acetone (4: 1) to obtain the title (pale orange solid, 1.4 g, 36.3%) and the other regio isomer. (pale orange solid, 609 mg, 16. 1%). Desired product :'H NMR (CDCI3) 8 4.08-4. 15 (m, 4H), 4.88 (s, 2H), 7.58 (s, 1H), 9.85 (s, 1H). The unwanted regio isomer :'H NMR (CDCI3) 8 4.06 (t, 2H, J = 5.2 Hz), 4.40 (t, 2H, J = 5. 2 Hz), 4.90 (s, 2H), 7.75 (s, 1H), 9.72 (s, 1H).

References:

WO2003/93279,2003,A1 Location in patent:Page/Page column 65-66

623564-41-0
2 suppliers
inquiry