![](/CAS/GIF/62596-26-3.gif)
Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester synthesis
- Product Name:Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester
- CAS Number:62596-26-3
- Molecular formula:C14H16O3
- Molecular Weight:232.27
![4-Oxocyclohexanecarboxylic acid](/CAS/GIF/874-61-3.gif)
874-61-3
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$7.00/250mg
![Benzyl bromide](/CAS/GIF/100-39-0.gif)
100-39-0
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$10.00/10g
![Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester](/CAS/GIF/62596-26-3.gif)
62596-26-3
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Yield:62596-26-3 92%
Reaction Conditions:
with potassium carbonate in N,N-dimethyl-formamide at 20; for 48 h;
Steps:
I Intermediate AA48: Benzyl 4-oxocyclohexanecarboxylate
To a solution of 4-oxocyclohexanecarboxylic acid AA47 (20.0 g, 0.141 mol) , potassium carbonate (38.9 g, 0.282 mol) in N, N-dimethylformamide (100 mL) was added (bromomethyl) benzene (28.8 g, 0.169 mol) . The mixture was stirred at room temperature for 2 days. The reaction mixture was poured into water (450 mL) and extracted with ethyl acetate (200 mL) for three times. The combined organic layers were washed with water (100 mL) , brine (100 mL) , dried over Na2SO4 (s), filtered and concentrated to give the crude product, which was purified by silica gel column chromatography (petroleum ether : ethyl acetate = 10 : 1 to 5 : 1) to give the title compound (30.0 g, 92 %yield) as yellow oil.1H NMR (300 MHz, DMSO-d6) δ 7.37 -7.26 (m, 5H) , 5.12 -5.05 (m, 2H) , 2.91 -2.79 (m, 1H) , 2.41 -2.31 (m, 2H) , 2.23 -2.08 (m, 4H) , 1.87 -1.72 (m, 2H) .
References:
WO2019/214610,2019,A1 Location in patent:Page/Page column 63
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![Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester](/CAS/GIF/62596-26-3.gif)
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![4-Hydroxybenzoic acid](/CAS/GIF/99-96-7.gif)
99-96-7
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$5.00/10g
![Cyclohexanecarboxylic acid, 4-oxo-, phenylmethyl ester](/CAS/GIF/62596-26-3.gif)
62596-26-3
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