4-(4-METHOXYPHENYL)-1-(4-PYRIDYLCARBONYL)SEMICARBAZIDE synthesis

Yield:6270-66-2 90%

Reaction Conditions:

in dichloromethane at 20; for 0.5 h;

Steps:

3.2.1. Synthesis of Isonicotinoylhydrazinecarboxamides 3

General procedure: Method A Isoniazid (1, 137.1 mg, 1.0 mmol) was suspended in anhydrous dichloromethane (5 mL), followed by the addition of the appropriate aryl isocyanate (2, 1.0 mmol) in one volume. The reaction mixture was stirred at room temperature for 30 min. A solid material was filtered off and recrystallised from boiling ethyl acetate. The reaction was monitored by TLC using the mixture n-hexane/ethyl acetate 3:1as an eluent.

References:

Rychtarcikova, Zuzana;Kratky, Martin;Gazvoda, Martin;Komloova, Marketa;Polanc, Slovenko;Kocevar, Marijan;Stolarikova, Jirina;Vinsova, Jarmila [Molecules,2014,vol. 19,# 4,p. 3851 - 3868]