Tert-Butyl 3-(Thiophen-2-Yl)Pyrrolidine-1-Carboxylate synthesis
- Product Name:Tert-Butyl 3-(Thiophen-2-Yl)Pyrrolidine-1-Carboxylate
- CAS Number:630121-93-6
- Molecular formula:C13H19NO2S
- Molecular Weight:253.36
630121-92-5
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630121-93-6
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Yield:630121-93-6 92%
Reaction Conditions:
with hydrogen;10% Pd/C in methanol at 20; under 3102.97 Torr;
Steps:
331B Example 331B; tert-butyl 3-thien-2-ylpyrrolidine-1-carboxylate
[2079] A solution of the product from Example 331A (1.25 g, 5 mmol) in methanol (100 mL) was treated with 20% palladium on carbon (0.7 g) and placed under 60 psi of hydrogen pressure at room temperature overnight. The solution was filtered and concentrated to give the desired compound (1.10 g, 92%). 1H NMR (300 MHz, CDCl3) δ7.17 (d, J=5, 1 Hz, 1H), 6.95 (dd, J=5, 4 Hz, 1H), 6.87 (m, 1H), 3.39-3.82 (m, 5H), 2.32 (m, 1H), 2.02 (m, 1H), 1.47 (m, 9H); MS (DCI/NH3) m/e 254 (M+H)+.
References:
US2003/229094,2003,A1 Location in patent:Page 125
101385-93-7
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